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Abstract On 18 November 2022, a large earthquake struck offshore southern Sumatra, generating a tsunami with 25 cm peak amplitude recorded at tide gauge station SBLT. OurW‐phase solution indicates a shallow dip of 6.2°, compatible with long‐period surface wave radiation patterns. Inversion of teleseismic body waves indicates a shallow slip distribution extending from about 10 km deep to near the trench with maximum slip of ∼4.1 m and seismic moment of  Nm (M_W7.3). Joint modeling of seismic and tsunami data indicates a shallow rigidity of ∼23 GPa. We find a low moment‐scaled radiated energy of , similar to that of the 2010M_W7.8 Mentawai event () and other tsunami earthquakes. These characteristics indicate that the 2022 event should be designated as a smaller moment magnitude tsunami earthquake compared to the other 12 well‐documented global occurrences since 1896. The 2022 event ruptured up‐dip of the 2007M_W8.4 Bengkulu earthquake, demonstrating shallow seismogenic capability of a megathrust that had experienced both a deeper seismic event and adjacent shallow aseismic afterslip. We consider seismogenic behavior of shallow megathrusts and concern for future tsunami earthquakes in subduction zones globally, noting a correlation between tsunami earthquake occurrence and subducting seafloor covered with siliceous pelagic sediments. We suggest that the combination of pelagic clay and siliceous sediments and rough seafloor topography near the trench play important roles in controlling the genesis of tsunami earthquakes along Sumatra and other regions, rather than the subduction tectonic framework of accretionary or erosive margin. 

Abstract Late‐stage functionalization (LSF) of drug molecules is an approach to generate modified molecules that retain functional groups present in the active drugs. Here, we report a study that seeks to characterize the potential value of high‐throughput desorption electrospray ionization mass spectrometry (HT DESI‐MS) for small‐scale rapid LSF. In conventional route screening, HT‐based DESI‐MS provides contactless, rapid analysis, reliable and reproducible data, minimal sample requirement, and exceptional tolerance to high salt concentrations. Ezetimibe (E), an established hypertension drug, is targeted for modification by LSF. C−H alkenylation and azo‐click reactions are utilized to explore this approach to synthesis and analytical characterization. The effect of choice of reactant, stoichiometry, catalyst, and solvent are studied for both reactions using high throughput DESI‐MS experiments. Optimum conditions for the formation of LSF products are established with identification by tandem mass spectrometry (MS/MS).